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Abstract
Promising Progress in CJD Treatment
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Successful treatment of the new variant form of Creutzfeldt-Jakob disease (vCJD) may be a matter of years away, according to expert and Nobel Prize winner Stanley Prusiner from the University of California at San Francisco. While scientists around the world are struggling to understand how this novel infectious protein jumps the species barrier, others are concentrating their efforts on finding targeted treatment approaches that may save lives.
Same Gene Different Drug
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Genes that control the cell's ability to deal with environmental toxins may also mediate other effects, such as resistance to therapeutic drugs. When designing such drugs, say researchers who study gene-environment interactions, it is essential to understand that the function of the target gene may be determined by its context.
Andrzej Krauze is an illustrator, poster maker, cartoonist, and painter who illustrates regularly for HMS Beagle, The Guardian, The Sunday Telegraph, Bookseller, and New Statesman.
Promising Progress in CJD Treatment
Molecular Biology of Prion Propagation - a recent review article from Current Opinion in Genetics & Development.
The Prion Folding Problem - a review of recent insights into conformational changes of the prion protein. From Current Opinion in Structural Biology.
Structure-Function Aspects of Prion Proteins - a review article from Current Opinion in Biotechnology.
Transmissible Spongiform Encephalopathies: Transmission, Mechanism of Disease, and Persistence - a review from Current Opinion in Microbiology.
Prion Biology and Diseases - a review of the book edited by Stanley Prusiner. From Trends in Neurosciences.
Sowing the Protein Seeds of Prion Propagation - a review of the data that supports the protein-only hypothesis. From the July 28, 2000 issue of Science. Registration required.
Resource on Prion Diseases - an extensive resource provided by the Department of Neurology of Johns Hopkins University.
Official Mad Cow Disease Home Page - provides links to more than 6,000 news articles and scientific papers on prion and neurodegenerative diseases, as well as background information on Stanley Prusiner. From the Sperling Biomedical Foundation.
Biology and Pathology of Prion Diseases - an online textbook of transmissible spongiform encephalopathies covering their discovery, genetics, and hypothesis concerning their role as infectious agents. The site is sponsored by Prionics, a firm from the University of Zurich.
Related HMS Beagle articles:
Same Gene Different Drug
Mechanistic Imperatives for the Evolution of Glutathione Transferases - reviews advances in understanding the catalytic mechanisms, structures, and evolution of glutathione transferases. From Current Opinion in Chemical Biology.
Glutathione and the Response of Malignant Cells to Chemotherapy - links GSH homeostasis with regulation of the multidrug-resistance-related protein and the control of apoptotic cell death. From Drug Discovery Today.
Mouse Genome Informatics - integrated access to data on the genetics, genomics, and biology of the laboratory mouse.
Related HMS Beagle articles: