Previous Cutting Edge Debates
What are the mechanisms underlying genetic mutations? Myriad enzymes are involved in DNA metabolism. Subtle changes in structure or amount of any of these enzymes can profoundly affect the mutational rate of a population of single-cell organisms or a group of cells within a multicellular organism.
HMS Beagle presents a dialogue among microbial geneticists and molecular oncologists to discuss state-of-the-art knowledge about controls of mutation rates. While early studies in the field often focused on mutations occurring in rapidly dividng cells, more emphasis is now being given to mutational mechanisms at play in nondividng cells, since quiescence is a common state for cells. On an intellectual level, learning about the means by which mutations are introduced and maintained is essential for understanding the molecular basis of evolution. On a practical level, acquisition of this knowledge should aid in treating and preventing emerging pathogen-based diseases as well as cancer.