Resources and information for parents of children with cancer . . . by parents of children with cancer.

Bibliography: Late Effects

Several Background Papers cited by the 2003 IOM Childhood Cancer Survivorship report are available as PDF files on the IOM web site. As of Sept. 2003: 7 papers are listed on various LE topics.

A bibliography of articles on cardiotoxicity is on a separate page:

2009

Pediatric Cancer Survivorship: The Childhood Cancer Survivor Study
May 10, 2009 J Clin Oncol

2009

Cost Effectiveness and Screening Interval of Lipid Screening in Hodgkin's Lymphoma Survivors. Aileen B. Chen et al., JCO Early Release, published online ahead of print Sep 14 2009. Abstract. "Conclusion: Lipid screening in survivors of HL, with statin therapy for screen-positive patients, improves survival and is cost effective. A screening interval of 3 years seems reasonable in the long-term follow-up of survivors of HL."

Cardiac or cardiopulmonary transplantation in childhood cancer survivors: An increasing need? Gill Levitt et al, European Journal of Cancer, early online view 9/8/09. A study of 43 patients, all were treated with anthracyclines (210–750 mg/m2) and 15 received cardiac radiation. The gist of the article is the stats on transplant success and a call for the medical profession to put childhood cancer survivors on heart-donor lists rather than exclude them as unlikely candidates.

Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Eric J. Chow et al, Pediatric Blood & Cancer, Volume 53, Issue 3, 2009, pp. 432-437. Abstract. "The risk of thyroid dysfunction and thyroid cancer was increased among childhood ALL survivors treated with craniospinal radiotherapy. In these individuals, long-term surveillance is warranted as no obvious plateau in risk was seen, even after 25 years of follow-up."

Oral health and dental anomalies in patients treated for leukemia in childhood and adolescence. Jlio CÈsar Cordova Maciel et al., Pediatric Blood & Cancer, Volume 53, Issue 3, 2009, pp. 361-365. Abstract. ALL treatment causes a significant increase in the number of dental anomalies, such as cavities, decayed or missing teeth, visible plaque, and gingival bleeding.

Voxel-Based Analysis of T2 Hyperintensities in White Matter during Treatment of Childhood Leukemia. W.E. Reddick et al., American Journal of Neuroradiology, 08/11/09. Abstract. These analyses identified specific white matter tracts involving predominantly the anterior, superior, and posterior corona radiata and superior longitudinal fasciculus, which were at increased risk for the development of T2-weighted hyperintensities during therapy for childhood ALL. These vulnerable regions may be the cause of subsequent cognitive difficulties consistently observed in survivors.

Prevalence and risk factors of radiation-induced growth hormone deficiency in childhood cancer survivors: A systematic review. Mulder RL et al., Cancer Treat Rev. 2009 Jul 27. PubMed Abstract. Conclusions: "GHD is a frequent consequence after CRT in childhood cancer survivors."

Insulin Resistance and Risk Factors for Cardiovascular Disease in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia. Kevin C. Oeffinger et al., JCO Early Release, published online ahead of print Jun 29 2009. Abstract. "In a study to determine the prevalence of insulin resistance and other risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia (ALL), it was reported that ALL survivors had an increased prevalence of insulin resistance in comparison with a cohort of older individuals from the same community"

A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia. Nina S. Kadan-Lottick et al., Blood First Edition Paper, prepublished online June 22, 2009. Abstract. This article concerns CCG 1922, the low-risk protocol for ALL in the early 1990s. "There were no group differences in the distribution of test scores or the parents' report of neurological complications, psychotropic drug use, and special education. Further analyses suggested for the dexamethasone group, older age of diagnosis was associated with worse neurocognitive functioning; for the prednisone group, younger age at diagnosis was associated with worse functioning. In conclusion, our study did not demonstrate any meaningful differences in long-term cognitive functioning of childhood ALL patients based on corticosteroid randomization."

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols. Martin Stanulla et al., Blood First Edition Paper, prepublished online June 17, 2009. Abstract. TPMT is discussed in a CCCF Newsletter. A good percentage of the population has the heterozygous or homozygous form of TPMT (an enzyme). The current article reports that children with these phenotypes are not more likely to get secondary cancers (especially AML and brain tumors).

Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia. Marika J. Harila et all, Pediatric Blood & Cancer, Volume 53, Issue 2, 2009. Abstract.

Pediatric Blood & Cancer, Volume 53, Issue 2, 2009, has several articles on fertility issues:

Bone Morbidity in Children treated for ALL. Strauss et al., JCO Strauss et al. 19 (12): 3066. (2001. PDF full text.

Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. Olsen JH et. al., J Natl Cancer Inst. 2009 Jun 3;101(11):806-13. PubMed Abstract. "Our studies identify a putative novel mechanism of drug resistance to the key antileukemic agent ASNase and present insights into the variations in response to ASNase in childhood ALL. This provides a platform for further optimization of asparaginase therapy with the potential of decreasing morbidity and improving outcome".

The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. Robison LL et al., J Clin Oncol. 2009 May 10;27(14):2308-18. Abstract.

Follow-up care after childhood cancer: Survivors' expectations and preferences for care. Michel G et al., Eur J Cancer. 2009 Mar 26. [Epub ahead of print]. Abstract.

Negative correlation between cerebrospinal fluid tau protein and cognitive functioning in children with acute lymphoblastic leukemia. Piotr T. Protas et al, Pediatric Blood & Cancer, Volume 53, Issue 1, 2009, p. 105-8. Abstract.

Long-Term Survivors of Childhood Cancers in the United States. Mariotto AB et al, Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1033-1040. PubMed abstract.

Psychological Status in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study. Lonnie K. Zeltzer et al., JCO Early Release, published online ahead of print Mar 2 2009. Abstract.

Second Neoplasms in Survivors of Childhood Cancer: Findings From the Childhood Cancer Survivor Study Cohort. Anna T. Meadows et al., JCO Early Release, published online ahead of print Mar 2 2009. Abstract.

Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Annemieke I. Buizer et al., Pediatric Blood & Cancer, Volume 52, Issue 4, 2009, pp. 447-454. Abstract.

Late effects on the urinary bladder in patients treated for cancer in childhood: A report from the Children's Oncology Group. Michael Ritchey et al., Pediatric Blood & Cancer, Volume 52, Issue 4, 2009, pp. 439-446. Abstract. "Childhood cancer survivors who have had pelvic or central nervous system surgery or have received alkylator-containing chemotherapy or pelvic radiotherapy as part of their cancer therapy may experience urinary bladder late effects." (The article is a review.)

Mammography rates low among childhood cancer survivors who underwent chest radiation. HemOnc today lay article. Breast Cancer Surveillance Practices Among Women Previously Treated With Chest Radiation for a Childhood Cancer, Kevin C. Oeffinger et al., JAMA. 2009;301:404-414. Abstract.

Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. S C Kaste et al., Leukemia (2009) 23, 104–108. Abstract. (Links to high blood pressure.)

Physical Activity and Quality of Life in Adult Survivors of Non-Hodgkin's Lymphoma. Keith M. Bellizzi et al., Journal of Clinical Oncology, Early Release, published online ahead of print Jan 12 2009. Abstract.

Assessment of selection bias in clinic-based populations of childhood cancer survivors: A report from the childhood cancer survivor study. Kirsten K. Ness, Pediatric Blood & Cancer, Volume 52, Issue 3, 2009, Pages: 379-386. Abstract. "Background: It is not known to what extent prevalence estimates of late effects among childhood cancer survivors derived from clinic based samples represent the actual estimates that would be derived if the entire population of childhood cancer survivors was recruited and evaluated for a particular outcome."

Parental needs for information related to neurocognitive late effects from pediatric cancer and its treatment. Christine L. Trask, Jennifer J. Greene Welch, Peter Manley, Elissa Jelalian, Cindy L. Schwartz. Pediatr Blood Cancer 2009;52:273–279. Abstract.

Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function. Fiona S. Anderson, Alicia S. Kunin-Batson. Pediatr Blood Cancer 2009;52:159–164. Abstract.

Long-Term Effects of High-Dose Chemotherapy and Radiation for Relapsed and Refractory Hodgkin's Lymphoma. Karyn A. Goodman et al, Journal of Clinical Oncology, Vol 26, No 32 (November 10), 2008: pp. 5240-5247. Abstract.

Total body bone measurements: A cross-sectional study in children with acute lymphoblastic leukemia during and following completion of therapy. Kara M. Kelly et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 33-38. Abstract.

Growth effects of methylphenidate among childhood cancer survivors: A 12-month case-matched open-label study. Bruce W. Jasper et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 39-43. Abstract. Methylphenidate, or MPH, is a stimulant medication. Conclusion: "Childhood cancer survivors taking MPH experience significant, though modest, deceleration of BMI and weight across the first year of MPH intervention. . . . Such findings are encouraging in light of increasing evidence that MPH mitigates some of the cognitive late-effects of cancer treatments. Nevertheless, on a case-by-case basis, clinicians should balance the intended benefits of MPH with potential growth effects in this vulnerable population".

Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. Niels J. van Casteren et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 108-112. Abstract.

A questionnaire based review of long-term follow-up programs for survivors of childhood cancer in Canada. G.M.T. Guilcher et al., Pediatric Blood & Cancer, Volume 52, Issue 1, 2009, pp. 113-115. Abstract. Thought in conclusion: "New models of care incorporating primary care physicians are necessary due to growing numbers of survivors.".

2008

Pediatric Neurocognitive Screening Method Found to Be More Accurate than Parental Observation. Krull KR et al., J Clin Oncol. 2008 Sep 1;26(25):4138-43. PubMed Abstract. Oncology Times summary by Robert H. Carlson.

Bone mineral density in young adult survivors of acute lymphoblastic leukemia. Inas H. Thomas et al. Cancer, 17 Oct 2008. Abstract. "In this long-term follow-up study of childhood ALL survivors, low BMD was found to be more prevalent than expected based on population normative data, specifically in men."

Longitudinal Changes in Obesity and Body Mass Index Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study. Edward G. Garmey et al. Journal of Clinical Oncology, Vol 26, No 28 (October 1), 2008: pp. 4639-4645. Abstract. "Compared with CCSS siblings, ALL survivors who were treated with cranial radiation therapy (CRT) had a significantly greater increase in BMI . . . . The rate of BMI increase was not significantly increased for ALL survivors who were treated with chemotherapy alone. Younger age at CRT exposure significantly modified risk."

Renal late effects in patients treated for cancer in childhood: A report from the Children's Oncology Group. Deborah P. Jones et al. Pediatric Blood & Cancer, Volume 51, Issue 6, 2008, pp. 724-731. Abstract. A review article.

Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. S C Kaste et al. Leukemia advance online publication 2 October 2008. Abstract. "Thus, kidney stones in childhood ALL survivors could herald the future deterioration of renal function and development of hypertension."

Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. Mertens AC et al. J Natl Cancer Inst. 2008 Oct 1;100(19):1368-79. Epub 2008 Sep 23. PubMed abstract. "In conclusion, children and adolescents diagnosed with cancer continue to be at elevated risk for death due to recurrences of the primary disease, and as a result of late effects of therapy," the authors write.

Medical Care in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Nathan PC et al. J Clin Oncol. 2008 Sep 20;26(27):4401-9. PubMed Abstract. "Conclusion: Despite a significant risk of late effects after cancer therapy, the majority of childhood cancer survivors do not receive recommended risk-based care."

Adult survivors of childhood cancer and their parents: experiences with survivorship and long-term follow-up. Kinahan KE et al. J Pediatr Hematol Oncol. 2008 Sep;30(9):651-8. Abstract.

Screening for Neurocognitive Impairment in Pediatric Cancer Long-Term Survivors. Krull KR et al. J Clin Oncol. 2008 Sep 1;26(25):4138-43. Abstract.

Scholastic achievement of children with lymphoma or Wilms tumor at the end of comprehensive education - A nationwide, register-based study. Päivi M. Lähteenmäki et al. International Journal of Cancer, published online July 23, 2008. Abstract.

Long-term follow-up of renal function after high-dose methotrexate treatment in children. Marika H. Grönroos et al. Pediatric Blood & Cancer, published online June 3, 2008. Abstract. "Our results show that HD-MTX treatment significantly decreases GFR and may cause albuminuria in pediatric cancer patients several years after treatment."

Modafinil controlled severe cancer-related fatigue. Article in HemOnc Today, June 2008. The author is Gary R. Morrow; he has published several articles on cancer fatigue treatment. Ritalin can possibly help too:

Neuropsychological Outcome in Chemotherapy-Only–Treated Children With Acute Lymphoblastic Leukemia. Nathalie C.A.J. Jansen et al. Journal of Clinical Oncology, Vol 26, No 18 (June 20), 2008: pp. 3025-3030. Abstract.

Cause-specific mortality and second cancer incidence after non-Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Elizabeth C. Bluhm et al. Blood, 15 April 2008, Vol. 111, No. 8, pp. 4014-4021. Abstract.

Obesity in long-term survivors of childhood acute lymphoblastic leukemia. S. Asner et al. Pediatr Blood Cancer 2008;51:118-122, 2008. Abstract.

A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Catherine C. Peterson et al. Pediatric Blood and Cancer, Volume 51 Issue 1, p. 99-104, 2008. Abstract. "Results support the presence of neuropsychological and academic sequelae for ALL survivors treated solely with chemotherapy and highlight the need for ongoing follow-up of children with ALL using a standardized neuropsychological test battery and research methodology."

Cause-specific mortality and second cancer incidence after non-Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Elizabeth C. Bluhm et al. Blood, 15 April 2008, Vol. 111, No. 8, pp. 4014-4021. Abstract.

Twenty five year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Rajen Mody, Suwen Li, Douglas C Dover, Stephen Sallan, Wendy Leisenring, Kevin C Oeffinger, Yutaka Yasui, Leslie L Robison, and Joseph P Neglia. Blood, March 2008. Lay articles: American Society of Hematology and University of Michigan Health System. Astract. Results of a study of about 4000 ALL survivors diagnosed between 1970-1986.

SIOP Symposium on Adolescent and Young Adult Oncology. Several articles in this special issue of Pediatric Blood and Cancer, including:

A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Catherine C. Peterson et al. Pediatric Blood & Cancer, Published Online: 5 Mar 2008. Abstract.

Bone mineral density deficits in survivors of childhood cancer: long-term follow-up guidelines and review of the literature. Wasilewski-Masker K et al. Pediatrics. 2008 Mar;121(3):e705-13. PubMed abstract.

Psychosocial Outcomes and Health-Related Quality of Life in Adult Childhood Cancer Survivors. Zeltzer LK et al. Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):435-46. PubMed abstract.

Timing of menarche among survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Eric J. Chow et al. Pediatric Blood and Cancer, Volume 50, Issue 4, p. 854-858. Abstract.

Decrease in peripheral muscle strength and ankle dorsiflexion as long-term side effects of treatment for childhood cancer. Annelies Hartman et al. Pediatric Blood and Cancer, Volume 50, Issue 4, Pages 833-837, 2008. Abstract.

Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma. A Andersson et al. British Journal of Cancer advance online publication 12 February 2008. Abstract.

Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood. Borgmann A, Zinn C, Hartmann R, Herold R, Kaatsch P, Escherich G, Möricke A, Henze G, von Stackelberg A; for the ALL-REZ BFM Study Group. Eur J Cancer. 2008 Jan;44(2):257-268. PubMed Abstract.

2007

Body composition, exercise and energy expenditure in survivors of acute lymphoblastic leukaemia. Justin T. Warner. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 456-61. Abstract.

Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease? Kevin C. Oeffinger. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 456-461. Abstract.

Skeletal toxicities of treatment in children with cancer. Sue C. Kaste. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 469-473. Abstract.

Osteoporosis in children with cancer. Inge M. van der Sluis, Marry M. van den Heuvel-Eibrink. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 474-478. Abstract.

Osteonecrosis in children and adolescents with cancer. Ronald D. Barr, Alessandra Sala. Pediatric Blood & Cancer Volume 50, Issue S2, 2008, pp. 483-485. Abstract.

Obesity and hypertension among children after treatment for acute lymphoblastic leukemia. Chow EJ, Pihoker C, Hunt K, Wilkinson K, Friedman DL. Cancer. 2007 Nov 15;110(10):2313-2. PubMed Abstract.

In a special issue of Chronic Illness, focusing on Childhood Cancer (December 2007), are the following articles:

Failure to lactate: A possible late effect of cranial radiation. Karen Johnston et al. Pediatric Blood & Cancer, Volume 50, Issue 3, 2008. pp. 721-722. Abstract.

Endocrine Late Effects of Childhood Cancer Therapy: A Report from the Children's Oncology Group. Horm Res. 2007 Dec 5;69(2):65-74. Nandagopal R, Laverdière C, Mulrooney D, Hudson MM, Meacham L. PubMed abstract.

Stress-related mental disorders in childhood cancer survivors. Nicole M. Schrag, Robert E. McKeown, Kirby L. Jackson, Steven P. Cuffe, Ronnie W. Neuberg. Pediatric Blood & Cancer Volume 50, Issue 1, 2008. Abstract. (Several other survivorship articles in the same issue.)

Young adult oncology: the patients and their survival challenges. Archie Bleyer. CA Cancer J Clin. 2007 Jul-Aug;57(4):242-55. PubMed abstract.

High-intensity strength training improves quality of life in cancer survivors. Ingrid C. De Backer et al. Acta Oncologica, Volume 46, Issue 8 2007 , pages 1143 - 1151. Abstract.

Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia. Kirsten K. Ness, K. Scott Baker, Donald R. Dengel, Nancy Youngren, Shalamar Sibley, Ann C. Mertens, James G. Gurney. Pediatric Blood and Cancer, Volume 49, Issue 7 , Pages 975 - 981. Abstract.

Long-term follow-up of children who underwent hematopoeitic cell transplant (HCT) for AML or ALL at less than 3 years of age. Joanna L. Perkins, Alicia S. Kunin-Batson, Nancy M. Youngren, Kirsten K. Ness, Kami J. Ulrich, Melissa J. Hansen, Anna Petryk, Julia Steinberger, Fiona S. Anderson, K. Scott Baker. Pediatric Blood and Cancer, Volume 49, Issue 7 , Pages 958 - 963. Abstract.

Growth and development after hematopoietic cell transplant in children. Sanders, JE. Bone Marrow Transplant. 2007 Oct 8. PubMed Abstract.

A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Leung, Wing et al. Medicine (Baltimore). 2007 Jul;86(4):215-24. PubMed Abstract.

Perspective: Is Childhood Cancer a Chronic Disease? J Ped Hem/Onc, Volume 29(9), September 2007, pp 595-597, D'Angio, Giulio J. MD.

Exercise echocardiography reveals subclinical cardiac dysfunction in young adult survivors of childhood acute lymphoblastic leukemia. M. Jarfelt, V. Kujacic, D. Holmgren, R. Bjarnason, B. Lannering. Pediatric Blood & Cancer, Volume 49, Issue 6, 2007, p. 835-840. Abstract.

B-type natriuretic peptide as a marker for cardiac dysfunction in anthracycline-treated children. Sanjeev Aggarwal, Michael D. Pettersen, Kanta Bhambhani, Joellyn Gurczynski, Ronald Thomas, Thomas L'Ecuyer. Pediatric Blood & Cancer, Volume 49, Issue 6, 2007, p. 812-816. Abstract.

Health status and quality of life in long-term survivors of childhood leukaemia: the impact of haematopoietic stem cell transplantation. Michel, G., et al. Bone Marrow Transplantation advance online publication 20 August 2007. Abstract. "In spite of a higher risk of physical adverse events in the transplanted group, very few clinically significant differences in QoL are detectable."

Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer: A Report From the Children's Oncology Group. Paul C. Nathan, Sunita K. Patel, Kimberley Dilley, Robert Goldsby, Jeanne Harvey, Chad Jacobsen, Nina Kadan-Lottick, Karen McKinley, Anne K. Millham, Ida Moore, M. Fatih Okcu, Catherine L. Woodman, Pim Brouwers, and F. Daniel Armstrong, for the Children's Oncology Group. Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer. Arch Pediatr Adolesc Med. 2007; 161(8): p. 798-806. Abstract.

Long-term endocrine sequelae of childhood cancer. Rutter MM, Rose SR. Curr Opin Pediatr. 2007 Aug;19(4):480-487. PubMed Abstract.

High incidence of meningioma in cranial irradiated survivors of childhood acute lymphoblastic leukemia. Yacov Goshen et al. Pediatric Blood & Cancer, Volume 49, Issue 3 , Pages 294 - 297, 2007. Abstract.

Factors associated with health-related quality of life in pediatric cancer survivors. Kathleen A. Meeske et al. Pediatric Blood & Cancer, Volume 49, Issue 3 , Pages 298 - 305, 2006. Abstract.

Clinical heart failure in a cohort of children treated with anthracyclines: a long-term follow-up study. Van Dalen EC et. al. Eur J Cancer. 2006 Dec;42(18):3191-8. Epub 2006 Sep 20. PubMed Abstract. Comment by Steven Lipshultz on MedScape.

Long-term cardiac outcomes following low-dose anthracycline exposure. J. A. Wright, S. Reimold, A. Turoff, S. Brooks, B. Huet, D. Eshelman, N. Winick, and K. Oeffinger ASCO Meeting Abstracts. 2007; 25(18_suppl): p. 9519. Abstract.

Longitudinal evaluation of early and late anthracycline cardiotoxicity in children with AML. Ursula Creutzi et al., Pediatric Blood and Cancer, Volume 48, Issue 7, Pages 651-662. Abstract.

Late cardiac effects of anthracycline containing therapy for childhood acute lymphoblastic leukemia. Mathias Rathe et. al., Pediatric Blood and Cancer, Volume 48, Issue 7, Pages 663-667. Abstract.

Anthracycline cardiotoxicity in long-term survivors of childhood cancer: The light is not at the end of the tunnel. Melissa M. Hudson, Pediatric Blood & Cancer, Volume 48, Issue 7, Pages 649 - 650, 2007. Abstract. "This study adds to the growing evidence that even low to moderate doses of anthracyclines might lead to progressive cardiac dysfunction. It is important that children treated with anthracyclines receive life long follow-up for signs of cardiomyopathy."

Medical Assessment of Adverse Health Outcomes in Long-term Survivors of Childhood Cancer. Maud M. Geenen et al., JAMA, Vol. 297, No. 24, June 27 2007. Abstract.

Self-report of somatic symptoms in survivors of childhood cancer: Effects of adaptive style. Nichole Jurbergs et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Hypertension and prehypertension in long-term survivors of childhood and adolescent cancer. Theresa B. Haddy et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

A stress echocardiography study of cardiac function during progressive exercise in pediatric oncology patients treated with anthracyclines. Astrid M. De Souza et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. Laura K. Campbell et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Psychological distress in long-term survivors of solid tumors diagnosed in childhood: A report from the childhood cancer survivor study. Brad J. Zebrack et al., Pediatric Blood & Cancer Volume 49, Issue 1, 2007. Abstract.

Risk of second malignant neoplasms after childhood leukemia and lymphoma: an international study. Maule, M., et al. J Natl Cancer Inst. 2007 May 16;99(10):790-800. PubMed Abstract.

QT prolongation and Torsades de Pointes in patients previously treated with anthracyclines. Trimis, Georgios MD., et al. Anticancer Drugs. 2007 Apr;18(4):493-8. PubMed Abstract.

Early indicators of dysmetabolic syndrome in young survivors of acute lymphoblastic leukemia in childhood as a target for preventing disease. Trimis, Georgios MD., et al. J Pediatr Hematol Oncol. 2007 May;29(5):309-14. PubMed Abstract.

Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma. Bassem I. Razzouk, et al. J Clin Oncol. 2007 Apr 1;25(10):1183-9. PubMed abstract.

Obesity in adult survivors of childhood acute lymphoblastic leukemia: A follow-up report from the Childhood Cancer Survivor Study. E. G. Garmey, Q. Liu, C. A. Sklar, L. R. Meacham, M. Stovall, Y. Yasui, L. L. Robison, and K. C. Oeffinger ASCO Meeting Abstracts. 2007; 25(18_suppl): p. 9518. Abstract.

Cumulative Incidence of Secondary Neoplasms as a First Event After Childhood Acute Lymphoblastic Leukemia. Nobuko Hijiya et al. JAMA. 2007;297:1207-1215. Abstract.

Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia? Best Pract Res Clin Haematol. 2007;20(1):29-37. Richard A. Larson. PubMed Abstract.

Suicidal Ideation and Attempts in Adult Survivors of Childhood Cancer. Christopher J. Recklitis, Rebecca A. Lockwood, Monica A. Rothwell, Lisa R. Diller. Journal of Clinical Oncology, Vol 24, No 24 (August 20), 2006: pp. 3852-3857. Abstract. Free full text available. Also see the related comments.

Comparison of Long-Term Neurocognitive Outcomes in Young Children With Acute Lymphatic Leukemia Treated With Cranial Radiation or High-Dose or Very High-Dose Intravenous Methotrexate. Ian J. Cohen. J Clin Oncol 25:734-735, 2007. Abstract.

Osteonecrosis in children and adolescents with cancer? An adverse effect of systemic therapy. Alessandra Sala, et al. Eur J Cancer. 2007 Mar;43(4):683-9. PubMed abstract. Offers suggestions for prevention (during treatment).

The late effects of childhood cancer therapy. Dickerman JD. Pediatrics. 2007 Mar;119(3):554-68. PubMed abstract.

Late cardiotoxicity after treatment for Hodgkin lymphoma. Berthe M. P. Aleman, et al. Blood. 2007 Mar 1;109(5):1878-86. PubMed abstract.

Mortality among 5-year survivors of cancer diagnosed during childhood or adolescence in British Columbia, Canada. Amy C. MacArthur. Pediatric Blood & Cancer, Volume 48, Issue 4, 2007, p. 460-7. Abstract.

Long-term effects of treatments for childhood cancers. Alvarez, Jorge A, et al. Curr Opin Pediatr. 2007 Feb;19(1):23-31. PubMed abstract.

Risk of a second malignant neoplasm among 5-year survivors of cancer in childhood and adolescence in British Columbia, Canada. Pediatric Blood & Cancer, Volume 48, Issue 4, 2007, Pages: 453-459. Amy C. MacArthur et al. Abstract.

2006

Experience of Fatigue in Adolescents Living With Cancer. Ream, Emma et al., Cancer Nursing, July/Aug 2006, p. 317-326.

Late-Occurring Stroke Among Long-Term Survivors of Childhood Leukemia and Brain Tumors: A Report From the Childhood Cancer Survivor Study. Journal of Clinical Oncology, Vol 24, No 33 (November 20), 2006: pp. 5277-5282, J Clin Oncol 24:5277-5282, 2006. Abstract.

Comparison of Long-Term Neurocognitive Outcomes in Young Children With Acute Lymphoblastic Leukemia Treated With Cranial Radiation or High-Dose or Very High-Dose Intravenous Methotrexate. Brenda J. Spiegler, Kimberly Kennedy, Ronnen Maze, Mark L. Greenberg, Sheila Weitzman, Johann K. Hitzler, Paul C. Nathan, J Clin Oncol 24:3858-3864, 2006. Abstract.

Mortality experiences among 15+ year survivors of childhood and adolescent cancers. Shauna C.W. Lawless, Puja Verma, Daniel M. Green, Martin C. Mahoney. Pediatric Blood & Cancer, Volume 48, Issue 3 , Pages 333 - 338. Published Online: 1 Feb 2006. Abstract. Excerpt from abstract: "...overall mortality among 15+ year survivors without a relapse appears to be comparable to the general population. The leading cause of death among 15+ year survivors is second malignancy in this study, which represents a novel and important finding in terms of long-term follow-up."

Moyamoya syndrome following childhood acute lymphoblastic leukemia. Akira Kikuchi, Miho Maeda, Ryoji Hanada, Yuri Okimoto, Koichi Ishimoto, Takashi Kaneko, Koichiro Ikuta, Masahiro Tsuchida, On behalf of the Tokyo Children's Cancer Study Group (TCCSG). Pediatric Blood & Cancer, Volume 48, Issue 3 , Pages 268 - 272, Published Online: 13 Apr 2006. Abstract.

Neurocognitive effects of treatment for childhood cancer. Ment Retard Dev Disabil Res Rev. 2006;12(3):184-91. Butler RW, Haser JK. PubMed abstract.

Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Peter D. Cole, Barton A. Kamen. Volume 12, Issue 3 , Pages 174 - 183. Abstract.

****Chronic Health Conditions in Adult Survivors of Childhood Cancer. Kevin Oeffinger et al. NEJM Volume 355:1572-1582, October 12, 2006, Number 15. Full Text. Abstract. "Required Reading". Perspective article in the same issue by Philip Rosoff. Full Text.

Long-term cardiac follow-up in survivors of a malignant bone tumour. C. A. J. Brouwer, J. A. Gietema, M. P. van den Berg, M. T. E. Bink-Boelkens, N. J. Elzenga, J. Haaksma, W. A. Kamps, J. M. Vonk, E. G. E. de Vries & A. Postma. Annals of Oncology Advance Access published July 20, 2006. PubMed Abstract.

Female Survivors of Childhood Cancer: Preterm Birth and Low Birth Weight Among Their Children. Lisa B. Signorello, Sarah S. Cohen, Cristina Bosetti, Marilyn Stovall, Catherine E. Kasper, Rita E. Weathers, John A. Whitton, Daniel M. Green, Sarah S. Donaldson, Ann C. Mertens, Leslie L. Robison, John D. Boice, Jr. Journal of the National Cancer Institute, Vol. 98, No. 20, 1453-1461, October 18, 2006. Abstract. Online lay summary: Radiotherapy Threatens Babies Born to Childhood Cancer Survivors. NCI Bulletin. "Women who were exposed to radiotherapy during treatment for childhood cancer - especially pelvic radiation - are more likely to deliver infants who are born prematurely."

Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer. 2006 Aug 7. Gurney JG, Ness KK, Sibley SD, O'leary M, Dengel DR, Lee JM, Youngren NM, Glasser SP, Baker KS. Abstract.

Loss of antibodies and response to (re-)vaccination in children after treatment for acute lymphocytic leukemia: a systematic review. van Tilburg CM, Sanders EA, Rovers MM, Wolfs TF, Bierings MB. Leukemia. 2006 Aug 3. Abstract.

Behavioral and educational limitations after chemotherapy for childhood acute lymphoblastic leukemia or Wilms tumor. Buizer AI, de Sonneville LM, van den Heuvel-Eibrink MM, Veerman AJ. PubMed abstract.

Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Haddy TB, Mosher RB, Nunez SB, Reaman GH. Pediatr Blood Cancer. 2006 Feb;46(2):258-61. PubMed Abstract.

Bone mineral density and bone turnover in young adult survivors of childhood acute lymphoblastic leukaemia. M Jarfelt, H Fors, B Lannering and R Bjarnason. European Journal of Endocrinology, Vol 154, Issue 2, 303-309. Abstract.

High incidence of late effects found in Hodgkin's lymphoma survivors, following recall for breast cancer screening. Greenfield DM, Wright J, Brown JE, Hancock BW, Davies HA, O'Toole L, Eiser C, Coleman RE, Ross RJ. Br J Cancer. 2006 Feb 27;94(4):469-72. PubMed abstract.

Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Bassal M, Mertens AC, Taylor L, Neglia JP, Greffe BS, Hammond S, Ronckers CM, Friedman DL, Stovall M, Yasui YY, Robison LL, Meadows AT, Kadan-Lottick NS. J Clin Oncol. 2006 Jan 20;24(3):476-83. PubMed abstract.

Decreased numbers of CD4+ T lymphocytes in peripheral blood after treatment of childhood acute lymphoblastic leukemia. Mazur B, Szczepanski T, Karpe J, Sonta-Jakimczyk D, Bubala H, Torbus M. Leukemia Research Volume 30, Issue 1 , January 2006, Pages 33-36. "The results showed that most parameters in children 1 year after ALL treatment completion were similar to healthy children. However, we observed persistently low CD4+ T cell numbers, both CD45RA+ as well as CD45RO+ subsets as compared to the control group. This might reflect decreased regenerative potential of immunological system in children 1 year after ALL treatment." PubMed abstract.

Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Reddick WE, Shan ZY, Glass JO, Helton S, Xiong X, Wu S, Bonner MJ, Howard SC, Christensen R, Khan RB, Pui CH, Mulhern RK. Cancer. 2006 Jan 12. Abstract.

2006, Feb., Pediatric Blood and Cancer. About 10 articles on childhood cancer survivorship issues.

Experience of fatigue in adolescents living with cancer. Ream E, Gibson F, Edwards J, Seption B, Mulhall A, Richardson A. Cancer Nurs. 2006 Jul-Aug;29(4):317-26. PubMed Abstract.

2005

Special Issue on Surviving Pediatric Cancer: Research Gains and Goals. J Pediatr Psychol, Contents: Volume 30, Number 1: January/February 2005. Table of Contents for this issue. Example: Neurocognitive outcomes in survivors of childhood cancer, Moore B.

Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Pediatr Blood Cancer 20 Dec 2005 46(2): p. 258. Haddy TB, Mosher RB, Nunez SB, Reaman GH. Abstract.

Health Insurance Coverage in Survivors of Childhood Cancer: The Childhood Cancer Survivor Study. Elyse R. Park, Frederick P. Li, Yan Liu, Karen M. Emmons, Arthur Ablin, Leslie L. Robison, Ann C. Mertens. Journal of Clinical Oncology, Vol 23, No 36 (December 20), 2005: pp. 9187-9197. Abstract.

Risk of Adverse Events After Completion of Therapy for Childhood Acute Lymphoblastic Leukemia. Ching-Hon Pui, Deqing Pei, John T. Sandlund, Dario Campana, Raul C. Ribeiro, Bassem I. Razzouk, Jeffrey E. Rubnitz, Scott C. Howard, Nobuko Hijiya, Sima Jeha, Cheng Cheng, James R. Downing, William E. Evans, Mary V. Relling, Melissa Hudson. Journal of Clinical Oncology, Vol 23, No 31 (November 1), 2005: pp. 7936-7941. Abstract.

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Annemieke I.  Buizer, Leo M.J.  de Sonneville, Marry M.  Van den Heuvel-Eibrink, Charles  Njiokiktjien and Anjo J.P. Veerman. Journal of the International Neuropsychological Society (2005), 11: 554-565 Cambridge University Press. Abstract.

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Maru Barrera, Amanda K. Shaw, Kathy N. Speechley, Elizabeth Maunsell, Lisa Pogany, M.Sc. Cancer Volume 104, Issue 8 , Pages 1751 - 1760. Abstract.

Late Effects of Pelvic Rhabdomyosarcoma and Its Treatment in Female Survivors. Sheri L. Spunt, Teresa A. Sweeney, Melissa M. Hudson, Catherine A. Billups, Matthew J. Krasin, Allison L. Hester. Journal of Clinical Oncology, Vol 23, No 28 (October 1), 2005: pp. 7143-7151. Abstract.

Metabolic Syndrome in Children and Adolescents With Acute Lymphoblastic Leukemia After the Completion of Chemotherapy. Journal of Pediatric Hematology/Oncology. 27(9):499-501, September 2005. Kourti, Maria MD, MSc; Tragiannidis, Athanassios MD; Makedou, Areti MD, PhD; Papageorgiou, Theodotis MD, PhD; Rousso, Israel MD, PhD; Athanassiadou, Fani PhD, MD. Abstract.

Exercise capacity in apparently healthy survivors of pediatric cancer. Enrico De Caro, Francesca Fioredda, Maria Grazia Calevo, Attilio Smeraldi, Michele Saitta, Guia Hanau, Maura Faraci 1, Francesca Grisolia, Giorgio Dini, Giacomo Pongiglione and Riccardo Haupt. Arch Dis Child. Published Online First: 27 September 2005. Abstract.

Fatigue in Long-Term Hodgkin's Disease Survivors: A Follow-Up Study. Marianne J. Hjermstad, Sophie D. Fosså, Line Oldervoll, Harald Holte, Anne B. Jacobsen, Jon H. Loge. Journal of Clinical Oncology, Vol 23, No 27 (September 20), 2005: pp. 6587-6595. Abstract.

Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT. Paivi Holtta, D.D.S., Liisa Hovi, M.D., Ph.D., Ulla M. Saarinen-Pihkala, M.D., Ph.D., Jaakko Peltola, D.D.S., Ph.D., Satu Alaluusua, D.D.S., Ph.D. Cancer Volume 103, Issue 7 , Pages 1484 - 1493. Published Online: 28 Feb 2005. Full Text.

Chronic Progressive Cardiac Dysfunction Years After Doxorubicin Therapy for Childhood Acute Lymphoblastic Leukemia. Steven E. Lipshultz, Stuart R. Lipsitz, Stephen E. Sallan, Virginia M. Dalton, Suzanne M. Mone, Richard D. Gelber, Steven D. Colan. Journal of Clinical Oncology, Vol 23, No 12 (April 20), 2005: pp. 2629-2636. Abstract. CONCLUSION: Cardiac abnormalities were persistent and progressive after doxorubicin therapy. Inadequate ventricular mass with chronic afterload excess was associated with progressive contractile deficit and possibly reduced cardiac output and restrictive cardiomyopathy. The deficits were worst after highest cumulative doses of doxorubicin, but appeared even after low doses.

Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer ZE, Robison LL, Mertens AC. J Clin Oncol. 2005 Jun 1;23(16):3733-41. CONCLUSION: Long-term survivors of childhood and adolescent cancer who were treated with RT are at highest risk for developing NMSC. Educational efforts need to be directed to this population to facilitate early diagnosis of NMSC and reduction in sun exposure. PubMed abstract.

Bone Mineral Density in Childhood Survivors of Acute Lymphoblastic Leukemia Treated without Cranial Irradiation. Bernadette M. D. Brennan, Zulf Mughal, Stephen A. Roberts, Kate Ward, Stephen M. Shalet, Tim O. B. Eden, Andrew M. Will, Richard F. Stevens, and Judith E. Adams. The Journal of Clinical Endocrinology & Metabolism 90 (2):689–694 2005. PubMed Abstract.

Limitation of ankle range of motion in survivors of acute lymphoblastic leukemia: a cross-sectional study. Wright MJ, Halton JM, Barr RD. Med Pediatr Oncol. 1999 Apr;32(4):279-82. PubMed Abstract.

Obesity in adult survivors of childhood acute lymphoblastic leukemia: areport from the Childhood Cancer Survivor Study. J Clin Oncol. 2003 Apr 1;21(7):1359-65. Full text. Also go to the PubMed Abstract and then click on "related articles".

Prevalence and Correlates of Fatigue in Long-Term Survivors of Childhood Leukemia. Kathleen A. Meeske, Stuart E. Siegel, Denise R. Globe, Wendy J. Mack, Leslie Bernstein. Journal of Clinical Oncology, Vol 23, No 24 (August 20), 2005: pp. 5501-5510. Abstract.

Psychological Issues: The Jan/Feb 2005 Journal of Pediatric Psychology has several articles on this topic. You can read the contents/abstracts on their web site: Journal of Pediatric Oncology. Especially: Neurocognitive Interventions for children and Adolescents Surviving Cancer (Butler, R and Mulhern, R).

2004

Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. Link, K. et al. J Clin Endocrinol Metab. 2004 Oct;89(10):5003-12. PubMed abstract.

Ritalin Can Help Some Child Cancer Survivors, CancerPage version. Short-term efficacy of methylphenidate: a randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. Mulhern RK, Khan RB, Kaplan S, Helton S, Christensen R, Bonner M, Brown R, Xiong X, Wu S, Gururangan S, Reddick WE. J Clin Oncol. 2004 Dec 1;22(23):4743-51. PubMed Abstract.

Long-Term Survivors of Childhood Cancers: What Knowledge Have We Gained? Posted 11/23/2004, Mike M Hawkins, MedScape. From Nature Clinical Practice Oncology; reprint address - Centre for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. (Good lay version available online on MedScape 1/05.)

Chemotherapy for Bone Sarcoma Does Not Affect Fertility Rates or Childbirth. Hosalkar, Harish S MD; Henderson, Kathleen M CRNP; Weiss, Arthur MD; Donthineni, Rakesh MD; Lackman, Richard D MD. Clin Orthop. 2004 Nov; (428):256-60. 1(428):256-260, November 2004. PubMed abstract.

Childhood cancer survivors in the dark. Caprino D, Wiley TJ, Massimo L. J Clin Oncol. 2004 Jul 1;22(13):2748-50. PubMed abstract. Full text.

Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors. Oeffinger KC, Hudson MM. CA Cancer J Clin. 2004 Jul-Aug;54(4):208-36. PubMed Abstract. Full Text.

Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Maarten Mennes, MA 1, Peter Stiers, PhD 1, Erik Vandenbussche, PhD 1, Gertrui Vercruysse, MA 2, Anne Uyttebroeck, MD 2, Geert De Meyer, PhD 3, Stefaan W. Van Gool, MD, PhD. Pediatric Blood and Cancer, early view,10/2004.

Lack of benefit of early detection of relapse after completion of therapy for acute lymphoblastic leukemia. Jeffrey E. Rubnitz, MD, PhD , Nobuko Hijiya, MD, Yinmei Zhou, MS, Michaell L. Hancock, MS, Gaston K. Rivera, MD, Ching-Hon Pui, MD. Pediatric Blood and Cancer, early view, 10/2004.

Long-term Complications Following Childhood and Adolescent Cancer: Foundations for Providing Risk-based Health Care for Survivors. Kevin C. Oeffinger, MD1 and Melissa M. Hudson, MD. CA Cancer J Clin 2004; 54:208-236. Full text online.

Anthracycline Cardiotoxicity in Children. Leontine C.M. Kremer, M.D., Ph.D., and Huib N. Caron, M.D., Ph.D. N Engl J Med 351;2 July 8, 2004.

The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia. Steven E. Lipshultz, M.D., Nader Rifai, Ph.D., Virginia M. Dalton, M.S., P.N.P., Donna E. Levy, M.S., Lewis B. Silverman, M.D., Stuart R. Lipsitz, Sc.D., Steven D. Colan, M.D., Barbara L. Asselin, M.D., Ronald D. Barr, M.D., Luis A. Clavell, M.D., Craig A. Hurwitz, M.D., Albert Moghrabi, M.D., Yvan Samson, M.D., Marshall A. Schorin, M.D., Richard D. Gelber, Ph.D., and Stephen E. Sallan, M.D. N Engl J Med 351;2 July 8, 2004.

Genotoxicity of Therapeutic Intervention in Children with Acute Lymphocytic Leukemia. Sederick C. Rice1, Pamela Vacek3, Alan H. Homans1, Terri Messier2, Jami Rivers2, Heather Kendall1,4 and Barry A. Finette. Cancer Research 64, 4464-4471, July 1, 2004. Online abstract.

Health Care of Young Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study. Kevin C. Oeffinger, MD, Ann C. Mertens, PhD, Melissa M. Hudson, MD, James G. Gurney, PhD, Jacqueline Casillas, MD, Hegang Chen, PhD, John Whitton, MS6, Mark Yeazel, MD, MPH, Yutaka Yasui, PhD and Leslie L. Robison, PhD. Ann Fam Med 2004 2: 61-70. Abstract (full text available).

Long-term follow-up of survivors of childhood cancer in the UK. Taylor A, Hawkins M, Griffiths A, Davies H, Douglas C, Jenney M, Wallace WH, Levitt G. Pediatr Blood Cancer. 2004 Feb; 42(2):161-8. PubMed Abstract. Cancer page synopsis.

The Impact of Childhood Cancer on Adult Survivors’ Interpersonal Relationships. Terri Forsbach and Andrea Thompson. Child Care in Practice, Vol. 9, No. 2, 2003.

Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia. Chessells JM, Veys P, Kempski H, Henley P, Leiper A, Webb D, Hann IM. Br J Haematol. 2003 Nov;123(3):396-405. PubMed Abstract.

Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. Pui CH, Cheng C, Leung W, Rai SN, Rivera GK, Sandlund JT, Ribeiro RC, Relling MV, Kun LE, Evans WE, Hudson MM. N Engl J Med. 2003 Aug 14;349(7):640-9. Abstract.

Psychiatric hospitalizations among survivors of cancer in childhood or adolescence. Ross L, Johansen C, Dalton SO, Mellemkjaer L, Thomassen LH, Mortensen PB, Olsen JH. N Engl J Med. 2003 Aug 14;349(7):650-7. Abstract.

Height and Weight in Children Treated for Acute Lymphoblastic Leukemia: Relationship to CNS Treatment, Virginia Kimball Dalton, Montse Rue, Lewis B. Silverman, Richard D. Gelber, Barbara L. Asselin, Ronald D. Barr, Luis A. Clavell, Craig A. Hurwitz, Albert Moghrabi, Yvan Samson, Marshall Schorin, Nancy J. Tarbell, Stephen E. Sallan, Laurie E. Cohen, Journal of Clinical Oncology, Vol 21, Issue 15 (August), 2003: 2953-2960, 2003. Abstract.

Childhood Cancer Survivors Not Screened Enough. Author is Mark W. Yeazal, article reported to be in the Dec. 15 2003 online edition of Cancer. The link given is on the CancerPage.com web site.

Endocrine complications in pediatric patients with acute lymphoblastic leukemia, Scott C. Howard, Ching-Hon Pui. Blood Reviews, 2002, 16, 225–243. (Have a pdf of this article.) PubMed abstract.

Endocrine complications of pediatric brain tumors: case series and literature review. Muirhead SE, Hsu E, Grimard L, Keene D. Pediatr Neurol. 2002 Sep;27(3):165-70. PubMed abstract.

Health issues in survivors of childhood cancer. Castellino S, Hudson MM.South Med J. 2002 Sep;95(9):977-84. Review. No abstract available (but Medscape has the article, see the web-based article.)

Disturbance of pubertal development after cancer treatment. Muller J. Best Pract Res Clin Endocrinol Metab 2002 Mar;16(1):91-103. PubMed Abstract.

Research involving long-term survivors of childhood and adolescent cancer: methodologic considerations. Robison LL. Curr Probl Cancer. 2003 Jul-Aug;27(4):212-24. PubMed Abstract. (I have a print out of this article.)

Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME Jr, Ruccione K, Smithson WA, Robison LL. J Clin Oncol. 2001 Jul 1;19(13):3163-72. PubMed abstract. Full text.

Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. Mertens AC, Yasui Y, Neglia JP, Potter JD, Nesbit ME Jr, Ruccione K, Smithson WA, Robison LL. J Clin Oncol 2001 Jul 1;19(13):3163-72. PubMed Abstract. Medscape

Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. Moller TR, Garwicz S, Barlow L, Falck Winther J, Glattre E, Olafsdottir G, Olsen JH, Perfekt R, Ritvanen A, Sankila R, Tulinius H; Association of the Nordic Cancer Registries.; Nordic Society for Pediatric Hematology and Oncology. J Clin Oncol 2001 Jul 1;19(13):3173-81. PubMed Abstract. Medscape

Therapy-related myelodysplasia/leukemia (t-MDS/t-AML) following treatment of children with osteosarcoma. Bhatia, S, Krailo, M, Schwartz, C, Robison, L, Meyers, P. Proceedings of the American Society of Clinical Oncology 20: 1473a. 2001. ASCO Abstract.

Treatment of orbital rhabdomyosarcoma: Survival and late effects of treatment--Results of an international workshop. Oberlin O, Rey A, Anderson J, Carli M, Raney RB, Treuner J, Stevens MC. J Clin Oncol 19(1):197-204. 2001. PubMed Abstract.

Secondary acute myelogenous leukemia in patients previously treated for childhood renal tumors: a report from the National Wilms Tumor Study Group. Shearer P, Kapoor G, Beckwith JB, Takashima J, Breslow NE, Green DM. J Pediatr Hematol Oncol 23(2):109-111. 2001. PubMed Abstract.

Low incidence of second malignant neoplasms (SMN) following childhood acute lymphoblastic leukemia (ALL). Follow-up of the Children's Cancer Group (CCG) cohort. Bhatia, S, Sather, NH, Trigg, ME, Gaynon, PS, Robison, LL. Blood 96(11): 465a. 2000. Cannot find in Blood or PubMed.

Adult psychosocial outcomes in long-term survivors of acute lymphoblastic leukaemia and Wilms' tumour: a controlled study. Mackie E, Hill J, Kondryn H, McNally R. Lancet 2000 Apr 15;355(9212):1310-4. PubMed abstract.

1999 issue of the Journal of Pediatric Oncology Nursing has several articles of interest to survivors of childhood cancer. As of 2005, these articles on not on the web site for this journal.

Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: A Children's Cancer Group report. Kaleita, TA, Reaman, GH, MacLean, WE, Sather, HN, Whitt, JK. Cancer 85(8):1859-1865. 1999. PubMed Abstract.

Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck. Raney, RB, Asmar L, Vassilopoulou-Sellin, R, Klein MJ, Donaldson SS, Green J, Heyn R, Wharam, M, Glicksman, AS, Gehan Ea, Anderson J, Maurer HM. A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS) -II and -III. Med. Pediatr. Oncol. 33: 362-371. 1999 (can't find abstract; check med pediatr oncol site)

Pregnancy outcome after treatment for Wilms tumor. A report from the National Wilms Tumor Study Group (NWTSG). Proc Am Soc Clin Oncol 18:560a. Green DM, Peabody EM, Tait PP, Norkool PA, Breslow NE. 1999. ASCO Abstract.

Long-term survivors of childhood cancer: the late effects of therapy. Schwartz CL. Oncologist 1999;4(1):45-54. PubMed abstract. I have a pdf of this article.

Limitation of ankle range of motion in survivors of acute lymphoblastic leukemia: a cross-sectional study. Wright MJ, Halton JM, Barr RD. Med Pediatr Oncol. 1999 Apr;32(4):279-82. PubMed abstract.

Smoking in adult survivors of childhood acute lymphoblastic leukemia, Tao, ML, Guo, MD, Weiss R, Byrne, Mills, JL, Robison, LL, Zeltzer, LK. 1998. JNCI 90: 219-25. PubMed Abstract. (Note - this one is important because there will be a push to educate survivors about healthy lifestyles.)

Risk of cancer among offspring of childhood-cancer survivors. Sankila R, Olsen JH, Anderson H, Garwicz S, Glattre E, Hertz H, Langmar F, Lanning M, Møller T, Tulinius H. New England Journal of Medicine, May 7, 1998 338 (19):1339.

Legal and societal issues facing survivors of childhood cancer. Monaco GP, Fiduccia D, Smith G. Pediatr Clin North Am 1997 Aug;44(4):1043-58. PubMed abstract. I have a copy of this article.

Long-term survivors of childhood cancer. The medical consequences of cure. Marina N. Pediatr Clin North Am 1997 Aug;44(4):1021-42. PubMed abstract. I have a copy of this article.

Second primary cancers after childhood cancer. BMJ 1996;312:861-862 (6 April). Leslie L Robison. An Online Editorial. Note: this links to several good references.

Altered mineral metabolism and bone mass in children during treatment for acute lymphoblastic leukemia. alton JM, Atkinson SA, Fraher L, Webber C, Gill GJ, Dawson S, Barr RD. J Bone Miner Res. 1996 Nov;11(11):1774-83. PubMed abstract.

Bibliography - Neurocognitive Function

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Maru Barrera, Amanda K. Shaw, Kathy N. Speechley, Elizabeth Maunsell, Lisa Pogany, M.Sc. Cancer Volume 104, Issue 8 , Pages 1751 - 1760. Abstract.

A bibliography of journal articles on neurocognitive function after cancer treatment in kids. This can be a good list to have when dealing with the bureaucracy in setting up an IEP. Nancy Keene sent me this list in August 2000. It's not typed into a browser window, it's scanned in, so you have to load in each page one at a time.

The Jan/Feb 2005 Journal of Pediatric Psychology has several articles on this topic. You can read the contents/abstracts on their web site: Journal of Pediatric Oncology. Especially: Neurocognitive Interventions for children and Adolescents Surviving Cancer (Butler, R and Mulhern, R).

Educational Issues in Childhood Cancer, Armstrong, F.D., Horn, Marianna. School Psychology Quarterly Vol 10, No. 4, 1995 pp 292-304

Function-Specific Neuropsychological Assessment, Mulhern, Raymond, et al, Medical and Pediatric Oncology Supplement 1:34-40 (1998) (lists all the test used in a good workup--important! -NKeene) (no abstract available on PubMed)

Neurobehavioural Issues in Childhood Cancer, Armstrong, F.D., et al. School Psychology Review Vol 28, No 2, pp 194-203 1999. (talks about interventions -NKeene)

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