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    Drugs Used in Leukemia Treatments

    Generic Name Trade Name Common Name What it Is Used For
    amsacrine m-AMSA 4'(9-acridinylamido), topoisomerase II inhibitor AML, ANLL, ALL
    arsenic trioxide Trisenox As2O3 orphan drug PML
    asparaginase Elspar L-asparaginase Enzyme AML, ANLL, CLL, CML in lymphoid blas crisis
    busulfan Myleran BSF alkylating agent CML, CLL, PV
    alemtuzumab Campath-1H Campath - 1Hanti-CD52 humanized IgG1 monoclonal antibody CLL, NHL; waiting FDA approval, in compassionate use trials
    carmustein BCNU bis-chloronitrosourea alkylating agent ALL
    chlorambucil Leukeran chlorambucil alkylating agent CLL,HCL, NHL,
    cisplatin Platinol cis-platinum, CDDP heavy metal alkylating-like agent CLL, NHL
    cladribine Leustatin 2-chlorodeoxyadenosine, 2CdA purine antimetabolite HCL, CLL, NHL
    Compound 506U78 AraG arabinosyl guanosine purine analog still in trials
    cyclophosphamide Cytoxan CTX alkylating agent ALL, AML, CLL, NHL
    cytarabine Cytosar U AraC, cytosine arabinoside antimetabolite ALL, AML, CML, NHL
    dactinomycin Actinomycin ACT-D antitumor antibiotic ALL, AML, ANLL
    daunorubicin Cerubidine daunomycin, DNR anthracycline antitumor antibiotic ALL, AML, NHL
    decitabine - 5-AZA-2'-Deoxycytadine, DAC still in trials CML
    dexamethasone Decadron DXM adrenal corticosteroid CLL, NHL
    doxorubicin Adriamycin hydroxydaunorubicin anthracycline antitumor antibiotic ALL, AML, CLL, NHL
    epirubicin Ellence 4'-epidoxorubicin anthracycline antitumor antibiotic AML, NHL
    etoposide Vepesid VP-16 Plant alkaloid, topoisomerase II inhibitor ALL, AML, NHL
    fludarabine phosphate Fludara FAMP purine antimetabolite CLL,HCL, NHL, PLL
    gemtuzumab ozogamicin Mylotarg gemtuzumab CMA-676 CD 33 monoclonal antibody AML,
    homoharringtonine Cephalotaxine HHT antitumor antibiotic AML, NHL
    hydroxyurea Hydrea hydroxycarbamide antimetabolite CML, NHL, PV
    histimine dihydrochloride Maxamine - immunotherapeutic AML orphan drug used with Interleukin 2
    HuM195 investigatory HuM195 humanized anti-CD33 monoclonal antibody AML, PML still in clinical trials
    131 I LYM-1 Oncolym 131 I LYM-1 radioactive monoclonal antibody in clinical trials; more info as available.
    idarubicin hydrochloride Idamycin 4-demethoxydaunorubicin anthracycline antitumor antibiotic AML, ANLL
    ifosfamide Ifex, Mitoxana isophosphamide alkylating agent ALL, AML, NHL
    interleukin 2 Aldesleukin proleukin, IL-2 (T-cell growth factor)cytokine biological response modifier
    lactacystin - UCN01 inhibitor of ubiquitin-proteasome-dependent protein processing induces CLL cells to apoptosis; in trials
    2-ME - 2-methoxyestradiol Inhibitor of superoxide dismutase (SOD) can be used with antisense; still in trials
    melphalan Alkeran L-PAM, L-phenylalanine mustard alkylating agent CLL, NHL
    mercaptopurine Purinethal 6-mercaptopurine, 6-MP purine antimetabolite ALL, AML, ANLL
    mesna Mesnex, Uromitexan mesnum rescue drug to prevent hemorrhagic cystitis ALL, AML, ANLL
    methotexate Mexate MTX antimetabolite ALL, AML, MLL, NHL
    mitoxantrone Novantrone DHAD antitumor antibiotic AML, ANLL, CLL, NHL
    pegaspargase Oncospar PEG-L-asparaginase enzyme ALL, NHL,CLL, CML in blast crisis
    pentostatin Nipent 2'-deoxycoformycin purine antimetabolite HCL, NHL
    prednisone Deltasone prednisone Corticosteroid ALL, CLL, AML in lymphoid blast crisis, NHL
    rituximab Rituxan IDEC-C2B8 CD20 monoclonal antibody CLL, NHL
    STI571 investigatory STI571 transduction inhibitor PH+ CML still in clinical trials
    teniposide Vumon VM-26 plant alkyoid (toposomerase II inhibitor) ALL
    thioguanine - 6'-thioguanine, 6-TG purine antimetabolite ALL, ANLL, CML, NHL
    topotecan hydrochloride Hycamptin topotecan camptothecan; topoisomerase 1 inhibitor AML, MDS
    iodine I 131 Tositumomab Bexxar anti-B1 antibody CD20 antibody conjugated with radioactive iodine 131 AML, CLL, NHL still in trials
    tretinoin Vesanoid, Atragen all-trans-retinoic acid, ATRA retinoid (retinoic acid) derivative APL
    vinblastine sulfate Velban, Velsar vinblastine, VLB plant alkaloid (tubulin inhibitor) CML, NHL
    vincristine sulfate Oncovin vincristine, VCR plant alkaloid (tubulin inhibitor) ALL, AML, CLL, NHL

    ACRONYMS

      o ALL --Acute Lymphocytic Leukemia

      o AML --Acute Myloid Leukemia

      o ANLL -Acute nonlymphocytic leukemia

      o APL --Acute promyelocytic leukemia

      o CLL --Chronic Lymphoocytic Leukemia

      o CML --Chronic Myloid Leukemia

      o HCL --Hairy Cell Leukemia

      o MDS --Myelodysplastic Syndromes

      o MLL --Meningeal Lymphocytic Leukemia

      o NHL --Non-Hodgkin's Lymphoma

      o PLL --Prolymphocytic Leukemia

      o PV --Polycythemia Vera

    Biological Response Modifiers

    Generic Name Trade Name Common Name What it Is Used For
    epoitin alfa Epogen, Procrit erythropoitin inducer of erythrocyte production treatment of anemia
    filgrastim Neupogen G-CSF induces granulocyte production decreases incidence of infection, neutropenia
    alpha interferon-2A Roferon IFN-2A glycoprotein CML, HCL, NHL
    oprelvekin Neumega IL-11 supports growth of platelets decreases incidence of bleeding
    sargramostim Leukine, Prokine GM-CSF supports growth of granulocyte and monocyte precursers decreases incidence of infection, neutropenia
    thrombopoeitin investigational TPO stimulates growth of platelets decreases incidence of bleeding
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Last updated: Nov.15.2009

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